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#Platynereis

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Gaspar Jekely<p>Happy to be involved in UNICIL, our new Wellcome Trust Discovery project coordinated by <span class="h-card" translate="no"><a href="https://bsky.brid.gy/ap/did:plc:4r6khvkkt4wqz6iofl2eowsg" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>micromotility.bsky.social</span></a></span> </p><p>We will study ciliary dynamics across scales and organisms. A long-term <a href="https://biologists.social/tags/postdoc" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>postdoc</span></a> position will be available at Heidelberg University <span class="h-card" translate="no"><a href="https://xn--baw-joa.social/@uniheidelberg" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>uniheidelberg</span></a></span> shortly.</p><p><span class="h-card" translate="no"><a href="https://threads.net/@uniofexeter/" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>uniofexeter</span></a></span> press release: </p><p><a href="https://news.exeter.ac.uk/living-systems-institute/multi-million-project-to-crack-the-code-of-cilia-tiny-structures-with-big-impact-on-human-health/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">news.exeter.ac.uk/living-syste</span><span class="invisible">ms-institute/multi-million-project-to-crack-the-code-of-cilia-tiny-structures-with-big-impact-on-human-health/</span></a></p><p><a href="https://biologists.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biology</span></a> <a href="https://biologists.social/tags/microscopy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microscopy</span></a> <a href="https://biologists.social/tags/vEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>vEM</span></a> <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cilia</span></a> <a href="https://biologists.social/tags/platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>platynereis</span></a></p>
Gaspar Jekely<p>The final version of our paper on how <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> larvae respond to pressure has now been published</p><p><a href="https://elifesciences.org/articles/94306" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/articles/943</span><span class="invisible">06</span></a><br>.<br><a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a></p>
Didier AURELLE<p>Les capacités de <a href="https://ecoevo.social/tags/r%C3%A9g%C3%A9n%C3%A9ration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>régénération</span></a> de l'annélide <a href="https://ecoevo.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> dumerilii étudiées dans un nouvel article: <a href="https://www.cnrs.fr/fr/presse/nouvelle-avancee-dans-la-comprehension-de-la-regeneration-chez-un-ver-marin" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cnrs.fr/fr/presse/nouvelle-ava</span><span class="invisible">ncee-dans-la-comprehension-de-la-regeneration-chez-un-ver-marin</span></a></p>
Gaspar Jekely<p>New paper from Ikeda et al. on the biogenesis of chitin bristles in the annelid <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> with nice <a href="https://biologists.social/tags/vEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>vEM</span></a> reconstructions and a chitin synthase knockout.<br>Bristles are formed in a process of biological 3D printing. <span class="h-card" translate="no"><a href="https://mander.xyz/c/biology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>biology</span></a></span> <br><a href="https://biologists.social/tags/microscopy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microscopy</span></a> <br><a href="https://www.nature.com/articles/s41467-024-48044-3" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-024</span><span class="invisible">-48044-3</span></a></p>
PLOS Biology<p>.@SoerenHaefker @FRKT_labs &amp;co reveal high individual diversity in <a href="https://fediscience.org/tags/circadian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>circadian</span></a> behavioral patterns in the marine <a href="https://fediscience.org/tags/annelid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>annelid</span></a> <a href="https://fediscience.org/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a>, showing that behavioral rhythmicity is not correlated with oscillations in core clock genes. <span class="h-card" translate="no"><a href="https://mstdn.science/@maxperutzlabs" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>maxperutzlabs</span></a></span> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/49wKz9q" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/49wKz9q</span><span class="invisible"></span></a></p>
Gaspar Jekely<p>We have now published a new and massively extended/reworked preprint of the whole-body <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> larval <a href="https://biologists.social/tags/connectome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>connectome</span></a> with over 50 figures</p><p><a href="https://www.biorxiv.org/content/10.1101/2024.03.17.585258v1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.03.17.585258v1</span></a></p><p>All the analyses, plots and figures should be reproducible in <a href="https://biologists.social/tags/rstats" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>rstats</span></a> with the code provided:</p><p><a href="https://zenodo.org/doi/10.5281/zenodo.10825370" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">zenodo.org/doi/10.5281/zenodo.</span><span class="invisible">10825370</span></a></p><p><span class="h-card" translate="no"><a href="https://bird.makeup/users/zenodo_org" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>zenodo_org</span></a></span> </p><p>by querying our public <a href="https://biologists.social/tags/CATMAID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CATMAID</span></a> database:</p><p><a href="https://catmaid.jekelylab.ex.ac.uk" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">catmaid.jekelylab.ex.ac.uk</span><span class="invisible"></span></a></p><p><a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a> <span class="h-card" translate="no"><a href="https://mander.xyz/c/biology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>biology</span></a></span> <a href="https://biologists.social/tags/volumeEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>volumeEM</span></a> <br><span class="h-card" translate="no"><a href="https://biologists.social/@biorxivpreprint" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>biorxivpreprint</span></a></span></p>
Gaspar Jekely<p>Press release at <span class="h-card" translate="no"><a href="https://fediscience.org/@eLife" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>eLife</span></a></span> of our paper exploring the mechanism of pressure sensing by UV light sensors in <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> larvae<br> <br><a href="https://elifesciences.org/for-the-press/5f58b93c/plankton-use-uv-light-sensors-to-detect-pressure-change-and-avoid-getting-swept-away" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/for-the-pres</span><span class="invisible">s/5f58b93c/plankton-use-uv-light-sensors-to-detect-pressure-change-and-avoid-getting-swept-away</span></a></p><p>Luis Alberto Bezares Calderón et al. paper here:<br><a href="https://elifesciences.org/reviewed-preprints/94306" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/reviewed-pre</span><span class="invisible">prints/94306</span></a></p><p><a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a> <a href="https://biologists.social/tags/cilia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cilia</span></a> <a href="https://biologists.social/tags/zooplankton" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>zooplankton</span></a> <a href="https://biologists.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <span class="h-card" translate="no"><a href="https://mander.xyz/c/biology" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>biology</span></a></span></p>
Gaspar Jekely<p>EM stack of a golgi ribbon in a glial cell of <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a>, from Benvenuto et al.,:<br>"Evolution of the ribbon-like organization of the Golgi apparatus"<br>with small contribution from our lab.<br><a href="https://www.sciencedirect.com/science/article/pii/S2211124724001190?via%3Dihub" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sciencedirect.com/science/arti</span><span class="invisible">cle/pii/S2211124724001190?via%3Dihub</span></a><br><a href="https://biologists.social/tags/CellBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CellBiology</span></a> <a href="https://biologists.social/tags/volumeEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>volumeEM</span></a> <a href="https://biologists.social/tags/cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cell</span></a></p>
Gaspar Jekely<p>Registration is now open for this exciting <a href="https://biologists.social/tags/EMBO" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EMBO</span></a> lecture course on <a href="https://biologists.social/tags/Imaging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Imaging</span></a> <a href="https://biologists.social/tags/Marine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Marine</span></a> Organisms Across Scales.</p><p>I will speak about the latest incarnation of the <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> larval <a href="https://biologists.social/tags/connectome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>connectome</span></a> </p><p><a href="https://meetings.embo.org/event/24-marine-imaging" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">meetings.embo.org/event/24-mar</span><span class="invisible">ine-imaging</span></a></p>

How This Marine #Worm Can Tell Moonglow From Sunbeams
quantamagazine.org/how-this-ma

A marine #cryptochrome with an inverse photo-oligomerization mechanism nature.com/articles/s41467-023

"The marine #bristleworm #Platynereis dumerilii syncs its reproductive cycle with the phases of the #moon. #Scientists recently uncovered the structure of a #protein that helps it sense #moonlight."

Suite du fil

Hydrostatic pressure is a dominant cue in the sea and many aquatic organisms are known to respond to changes in pressure, however the neuronal mechanisms have remained unclear.
We studied the larvae of the marine #annelid #Platynereis and found that they respond to increases in pressure by increased upward swimming.
#neuroscience
2/9

For all electron microscopists out there:

"Crosshair, semi-automated targeting for electron microscopy with a motorised ultramicrotome"

Kimberly Meechan et al. 2022 @eLife from Yannick Schwab's lab at EMBL in collaboration with The Crick institute. elifesciences.org/articles/808

Presents a new method for reliably and "selectively targeting small regions of interest in a resin block by trimming with an ultramicrotome", powered by "user-friendly software to convert X-ray images of resin-embedded samples into angles and cutting depths for the ultramicrotome."

Reviewed by three outstanding electron microscopists: Christel Genaud, Song Pang, and Michaela Wilsch-Bräuninger.

A répondu dans un fil de discussion

What can you do with a #CATMAID server? Say, let's look at the #Drosophila (vinegar fly, often referred to as fruit fly) larval central nervous system, generously hosted by the #VirtualFlyBrain l1em.catmaid.virtualflybrain.o) or the #Platynereis (a marine annelid) server from the Jekely lab catmaid.jekelylab.ex.ac.uk/

First, directly interact by point-and-click: open widgets, find neurons by name or annotations, fire up a graph widget and rearrange neurons to make a neat synaptic connectivity diagram, or an adjacency matrix, or look at neuron anatomy in 3D. Most text–names, numbers–are clickable and filterable in some way, such as regular expressions.

Second, interact from other software. Head to r-catmaid natverse.org/rcatmaid/ (part of the #natverse suite by Philipp Schlegel @uni_matrix, Alex Bates and others) for an R-based solution from the Jefferis lab at the #MRCLMB. Includes tools such as #NBLAST for anatomical comparisons of neurons (see paper by Marta Costa et al. 2016 sciencedirect.com/science/arti ).

If R is not your favourite, then how about #python: the #navis package, again by the prolific @uni_matrix, makes it trivial, and works also within #Blender too for fancy 3D renderings and animations. An earlier, simpler version was #catpy by @csdashm github.com/ceesem/catpy , who also has examples on access from #matlab.

Third, directly from a #psql prompt. As in, why not? #SQL is quite a straightforward language. Of course, you'll need privileged access to the server, so this one is only for insiders. Similarly privileged is from an #ipython prompt initialized via #django from the command line, with the entire server-side API at your disposal for queries.

Fourth, and one of my favourites: from the #javascript console in the browser itself. There are a handful of examples here github.com/catmaid/CATMAID/wik but the possibilities are huge. Key utilities are the "fetchSkeletons" macro-like javascript function github.com/catmaid/CATMAID/wik and the NeuronNameService.getInstance().getName(<skeleton_id>) function.

Notice every #CATMAID server has its /apis/, e.g., at l1em.catmaid.virtualflybrain.o will list all GET or REST server access points. Reach to them as you please. See the documentation: catmaid.readthedocs.io/en/stab

In short: the data is there for you to reach out to, interactively or programmatically, and any fine mixture of the two as you see fit.

l1em.catmaid.virtualflybrain.orgCATMAID