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#epigenetics

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Hello
@MarkHoltom

“”We’ve got ours, pull up the gangplank #gangplankmentality

On a related note - -

@ MrSlanderer
{1 month ago:

Fun fact: Wild pigs that are introduced to a domesticated herd become tame within a couple weeks, whereas domesticated pigs that escape and join feral herds, become feral within a couple weeks, including developing oversized incisors
¿\youtube.com/watch?v=41PVbvsx6ps #BeyondFraming

#PlanetBee🌍🌏🌎🐝
oocities.org/etearthmission/BS #rise⚛️

#Epigenetics
#UAP

"Jo had no idea what a perfect correspondent heʼd found. Because the only audience my mom respects more than her entomological peers is small children…

"In September 2022, Jo presented his research to scientists at Shinshu University. Then at Tsukuba University and Saga University. He also graduated from second grade."

Reporter Annie Rosenthal's mother, Martha Weiss, helped discover that moths can remember things they learned when they were caterpillars. A young boy from Japan writes to her that he wants to replicate the experiment with swallowtail butterflies. With her help, he does. Then he sets his sights on an even more ambitious goal: testing whether butterflies can remember things *their parents* learned.

This was lovely and I teared up a bit just reading it. About generational memory, kindness, nurturing young scientists, Japanese bug culture, and more.

signalhill.fm/issue-one/#cater

Transcript (PDF): signalhill.fm/content/files/20

@SheDrivesMobility danke für die mutigen Worte. Ich habe einmal #HeribertPrantl geschrieben, dass sich Geschichte wiederholt. ER meinte damals: NEIN. Leider sehe ich den Faschismus weltweit wieder hervor kommen. Wie der #Faschismus seinen Weg nehmen kann, dazu habe ich mir Gedanken gemacht und bin zu dem Ergebnis gekommen, [These] dass wir wohl vielfach traumatisierte Wesen sind und das sich diese "Neurotisierung" eben auswirkt. siehe #Janov #epigenetics cigognenews.blogspot.com/2016/

Casey Brown was a great scientist and an amazing person. He could always make time to catch up with junior people, give encouragement or just joke about pretty much everything.

Now in his honour some of the leading scientist in #genomics and #complextraits have joint to record the Casey Brown #lectures.

From the basics of human #genetics, to #transcriptomics #epigenetics or #machinelearning for genomics. All free to watch.

m.youtube.com/playlist?list=PL

consent.youtube.comAvant d'accéder à YouTube

“Overall, the original ‘malaria hypothesis’ of Haldane that diseases such as thalassemia are polymorphisms with an advantage to heterozygotes in malarial environments has been proven correct.” #dna #isogg #malaria #epigenetics #population #genetics #geneadons

nature.com/articles/hdy201116

NaturePopulation genetics of malaria resistance in humans - HeredityThe high mortality and widespread impact of malaria have resulted in this disease being the strongest evolutionary selective force in recent human history, and genes that confer resistance to malaria provide some of the best-known case studies of strong positive selection in modern humans. I begin by reviewing JBS Haldane's initial contribution to the potential of malaria genetic resistance in humans. Further, I discuss the population genetics aspects of many of the variants, including globin, G6PD deficiency, Duffy, ovalocytosis, ABO and human leukocyte antigen variants. Many of the variants conferring resistance to malaria are ‘loss-of-function’ mutants and appear to be recent polymorphisms from the last 5000–10 000 years or less. I discuss estimation of selection coefficients from case–control data and make predictions about the change for S, C and G6PD-deficiency variants. In addition, I consider the predicted joint changes when the two β-globin alleles S and C are both variable in the same population and when there is a variation for α-thalassemia and S, two unlinked, but epistatic variants. As more becomes known about genes conferring genetic resistance to malaria in humans, population genetics approaches can contribute both to investigating past selection and predicting the consequences in future generations for these variants.

Entorno y estilo de vida paterno y efecto en la descendencia a través de efectos epigenéticos. Una revisión recién publicada en JARG: https://buff.ly/4ghfYAq #bianorbiotech #JARG #epigenetics #MaleFactor #Offspring #environment

Multifaceted paternal exposure...

SpringerLinkMultifaceted paternal exposures before conception and their epigenetic impact on offspring - Journal of Assisted Reproduction and GeneticsAs scientific research progresses, there is an increasing understanding of the importance of paternal epigenetics in influencing the health and developmental path of offspring. Prior to conception, the environmental exposures and lifestyle choices of fathers can significantly influence the epigenetic state of sperm, including DNA methylation and histone changes, among other factors. These alterations in epigenetic patterns have the potential for transgenerational transmission potential and may exert profound effects on the biological characteristics of descendants. Paternal epigenetic changes not only affect the regulation of gene expression patterns in offspring but also increase the risk to certain diseases. It is crucial to comprehend the conditions that fathers are exposed to before conception and the potential outcomes of these conditions. This understanding is essential for assessing personal reproductive decisions and anticipating health risks for future generations. This review article systematically summarizes and analyzes current research findings regarding how paternal pre-pregnancy exposures influence offspring as well as elucidates underlying mechanisms, aiming to provide a comprehensive perspective for an enhanced understanding of the impact that paternal factors have on offspring health.

FIV en modelo de ratón induce cambios en la descendencia, metilación del ADN espermático y efectos metabólicos durante varias generaciones (preprint). https://buff.ly/497Mend #bianorbiotech #preprints #mouse #IVF #epigenetics #sperm

In Vitro Fertilization induces...

bioRxiv · In Vitro Fertilization induces reproductive changes in male mouse offspring and has multigenerational effectsIn vitro fertilization (IVF) is a non-coital method of conception used to treat human infertility. Although IVF is viewed as largely safe, it is associated with adverse outcomes in the fetus, placenta, and adult offspring life. Because studies focusing on the effect of IVF on the male reproductive system are limited, we used a mouse model to assess the morphological and molecular effects of IVF on male offspring. We evaluated three developmental stages: 18.5-day fetuses and 12- and 39-week-old adults. Regardless of age, we observed changes in testicular-to-body weight ratios, serum testosterone levels, testicular morphology, gene expression, and DNA methylation. Also, sperm showed changes in morphology and DNA methylation. To assess multigenerational phenotypes, we mated IVF and naturally conceived males with wild-type females. Offspring from IVF males exhibited decreased fetal weight-to-placental weight ratios and changes in placenta morphology regardless of sex. At 12-weeks-of-age, offspring showed higher body weights and differences in glucose, triglycerides, insulin, total cholesterol, HDL and LDL/VLDL levels. Both sexes showed changes in gene expression in liver, testes and ovaries, and decreased global DNA methylation. Collectively, our findings demonstrate that male IVF offspring exhibit abnormal testicular and sperm morphology and molecular alterations and transmit defects multigenerationally. ### Competing Interest Statement The authors have declared no competing interest.

Hello! Hey Fediverse, once again. We are the Max Planck Institute of #Immunobiology and #Epigenetics. And we had to change our server.

Our community seems not really into this platform. Yet, we still believe that embracing open science with mastodon is important. For the time being, we investigate what to do with this account in the future and we will continue to cross-post our content.

Stay with us: ie-freiburg.mpg.de
#introduction #neuhier #sciencemastodon