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#optogenetic

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PLOS Biology<p><a href="https://fediscience.org/tags/Lysosomes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lysosomes</span></a> are crucial cellular degradation centers, but how can one selectively modulate their activity? This study describes novel <a href="https://fediscience.org/tags/optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetic</span></a> tools for the light-inducible manipulation of lysosomal physiology in cells &amp; in <a href="https://fediscience.org/tags/Celegans" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Celegans</span></a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/49WGds5" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">plos.io/49WGds5</span><span class="invisible"></span></a></p>
eLife<p>August's most-read Tools paper presents an <a href="https://fediscience.org/tags/optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetic</span></a> toolbox to reversibly control Rho <a href="https://fediscience.org/tags/GTPase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GTPase</span></a> activity for manipulating the barrier between <a href="https://fediscience.org/tags/endothelial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>endothelial</span></a> cells: <a href="https://elifesciences.org/articles/84364?utm_source=mastodon&amp;utm_medium=social&amp;utm_campaign=submissions_organic" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/articles/843</span><span class="invisible">64?utm_source=mastodon&amp;utm_medium=social&amp;utm_campaign=submissions_organic</span></a></p>
PLOS Biology<p>To migrate efficiently, neutrophils must polarize their cytoskeletal regulators along a single axis of motion. @JasonPTown &amp; @OWeinerLab use spatially-defined <a href="https://fediscience.org/tags/optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetic</span></a> control of a leading edge organizer to explore how <a href="https://fediscience.org/tags/neutrophil" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neutrophil</span></a>-like cells balance “decisiveness” (needed to polarize in one direction) with flexibility (to respond to new cues) <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3ZAldnx" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3ZAldnx</span><span class="invisible"></span></a></p>
PLOS Biology<p>How does the brain consider an animal's current actions when responding to its environment? <span class="h-card"><a href="https://neuromatch.social/@AndrewLeifer" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>AndrewLeifer</span></a></span> &amp;co use high-throughput <a href="https://fediscience.org/tags/optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetic</span></a> perturbations to show how motor-related signals influence a <a href="https://fediscience.org/tags/nematode" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nematode</span></a>’s response to <a href="https://fediscience.org/tags/TouchSensation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TouchSensation</span></a>. <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/455hWOh" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">plos.io/455hWOh</span><span class="invisible"></span></a></p>
PLOS Biology<p>.@xanderjones82 &amp;co describe Highlighter, an <a href="https://fediscience.org/tags/optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetic</span></a> tool for fine-scale eukaryotic <a href="https://fediscience.org/tags/GeneExpression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GeneExpression</span></a> control, and deploy it in <a href="https://fediscience.org/tags/plants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>plants</span></a> to enable cell-level hypothesis testing. @slcuplants @RobertoHofmann1 <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>PLOSBiology</span></a> <a href="https://plos.io/3RvZvzh" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">plos.io/3RvZvzh</span><span class="invisible"></span></a></p>
Gaspar Jekely<p>Our favourite <a href="https://biologists.social/tags/Platynereis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Platynereis</span></a> <a href="https://biologists.social/tags/opsin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>opsin</span></a> now in the mammalian brain as a new <a href="https://biologists.social/tags/optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetic</span></a> tool!</p><p>"Here we ... found that the Platynereis dumerilii ciliary opsin ... is an efficient, versatile, light-activated bistable GPCR that can suppress synaptic transmission in mammalian neurons with high temporal precision in-vivo "</p><p><a href="https://www.biorxiv.org/content/10.1101/2023.07.01.547328v1" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">23.07.01.547328v1</span></a></p><p><a href="https://biologists.social/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a> <a href="https://biologists.social/tags/GPCR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GPCR</span></a></p>
Jonas Wietek :vibing:<p>🚨<a href="https://mstdn.science/tags/Optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Optogenetic</span></a> preprint alert🚨<br>Check out PdCO:<br>Light-controlled inhibition of synaptic transmission via the inhibitory <a href="https://mstdn.science/tags/GPCR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GPCR</span></a> pathway. <a href="https://mstdn.science/tags/optogenetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>optogenetics</span></a> <a href="https://mstdn.science/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a></p><p>Link:</p>
El Duvelle<p>New <a href="https://neuromatch.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Neuroscience</span></a> paper, with potential implications for the pyramidal-cell specificity of some <a href="https://neuromatch.social/tags/Optogenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Optogenetic</span></a> stimulations:</p><blockquote><p>“our results challenge the use of CaMKIIα promoter-driven protein expression as a selective tool in targeting cortical glutamatergic neurons using viral vectors”</p></blockquote><p><a href="https://www.eneuro.org/content/10/4/ENEURO.0070-23.2023" rel="nofollow noopener noreferrer" target="_blank">CaMKIIα Promoter-Controlled Circuit Manipulations Target Both Pyramidal Cells and Inhibitory Interneurons in Cortical Networks</a><br><a href="https://neuromatch.social/tags/NeuroPaper" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>NeuroPaper</span></a> <a href="https://neuromatch.social/tags/Optogenetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Optogenetics</span></a></p>