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Europe Says<p><a href="https://www.europesays.com/2196996/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">europesays.com/2196996/</span><span class="invisible"></span></a> Do spicy foods help or hurt your gut health? <a href="https://pubeurope.com/tags/america" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>america</span></a> <a href="https://pubeurope.com/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>bacteria</span></a> <a href="https://pubeurope.com/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>brain</span></a> <a href="https://pubeurope.com/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> <a href="https://pubeurope.com/tags/Capsaicin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Capsaicin</span></a> <a href="https://pubeurope.com/tags/Cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cell</span></a> <a href="https://pubeurope.com/tags/Conjugation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Conjugation</span></a> <a href="https://pubeurope.com/tags/Cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cytokines</span></a> <a href="https://pubeurope.com/tags/diet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>diet</span></a> <a href="https://pubeurope.com/tags/Entertainment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Entertainment</span></a> <a href="https://pubeurope.com/tags/Gene" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Gene</span></a> <a href="https://pubeurope.com/tags/health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>health</span></a> <a href="https://pubeurope.com/tags/Metabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Metabolism</span></a> <a href="https://pubeurope.com/tags/Metabolites" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Metabolites</span></a> <a href="https://pubeurope.com/tags/microbiome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiome</span></a> <a href="https://pubeurope.com/tags/obesity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>obesity</span></a> <a href="https://pubeurope.com/tags/Phytochemical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Phytochemical</span></a> <a href="https://pubeurope.com/tags/Receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Receptor</span></a> <a href="https://pubeurope.com/tags/sports" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sports</span></a> <a href="https://pubeurope.com/tags/Tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tumor</span></a> <a href="https://pubeurope.com/tags/UnitedStates" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>UnitedStates</span></a> <a href="https://pubeurope.com/tags/UnitedStatesOfAmerica" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>UnitedStatesOfAmerica</span></a> <a href="https://pubeurope.com/tags/US" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>US</span></a> <a href="https://pubeurope.com/tags/USA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>USA</span></a></p>
Bytes Europe<p>Leading health organizations release guidance on nutrition support for GLP-1 obesity therapies <a href="https://www.byteseu.com/1061025/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">byteseu.com/1061025/</span><span class="invisible"></span></a> <a href="https://pubeurope.com/tags/Bone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bone</span></a> <a href="https://pubeurope.com/tags/EDUCATION" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>EDUCATION</span></a> <a href="https://pubeurope.com/tags/GLP1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GLP1</span></a> <a href="https://pubeurope.com/tags/Health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Health</span></a> <a href="https://pubeurope.com/tags/Medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Medicine</span></a> <a href="https://pubeurope.com/tags/muscle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>muscle</span></a> <a href="https://pubeurope.com/tags/Nutrition" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nutrition</span></a> <a href="https://pubeurope.com/tags/Obesity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Obesity</span></a> <a href="https://pubeurope.com/tags/placebo" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>placebo</span></a> <a href="https://pubeurope.com/tags/Receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Receptor</span></a> <a href="https://pubeurope.com/tags/Research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Research</span></a> <a href="https://pubeurope.com/tags/WeightLoss" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>WeightLoss</span></a></p>
Europe Says<p><a href="https://www.europesays.com/2073142/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">europesays.com/2073142/</span><span class="invisible"></span></a> Estrogen-related receptors could be a key to repairing energy metabolism and muscle fatigue <a href="https://pubeurope.com/tags/Aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Aging</span></a> <a href="https://pubeurope.com/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>brain</span></a> <a href="https://pubeurope.com/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cancer</span></a> <a href="https://pubeurope.com/tags/Cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cell</span></a> <a href="https://pubeurope.com/tags/CellMetabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CellMetabolism</span></a> <a href="https://pubeurope.com/tags/Dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Dementia</span></a> <a href="https://pubeurope.com/tags/Energy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Energy</span></a> <a href="https://pubeurope.com/tags/Estrogen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Estrogen</span></a> <a href="https://pubeurope.com/tags/exercise" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>exercise</span></a> <a href="https://pubeurope.com/tags/fatigue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fatigue</span></a> <a href="https://pubeurope.com/tags/Food" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Food</span></a> <a href="https://pubeurope.com/tags/genes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>genes</span></a> <a href="https://pubeurope.com/tags/Heart" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Heart</span></a> <a href="https://pubeurope.com/tags/HeartDisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>HeartDisease</span></a> <a href="https://pubeurope.com/tags/hormone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>hormone</span></a> <a href="https://pubeurope.com/tags/MetabolicDisorders" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MetabolicDisorders</span></a> <a href="https://pubeurope.com/tags/Metabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Metabolism</span></a> <a href="https://pubeurope.com/tags/Mitochondria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Mitochondria</span></a> <a href="https://pubeurope.com/tags/MultipleSclerosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MultipleSclerosis</span></a> <a href="https://pubeurope.com/tags/Muscle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Muscle</span></a> <a href="https://pubeurope.com/tags/Receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Receptor</span></a> <a href="https://pubeurope.com/tags/research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>research</span></a> <a href="https://pubeurope.com/tags/Sclerosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sclerosis</span></a></p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Receptor</span></a> <a href="https://mstdn.science/tags/Binding" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Binding</span></a> Specificity of a <a href="https://mstdn.science/tags/Bovine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bovine</span></a> <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Influenza</span></a> Virus, BioRxIV: <a href="https://www.biorxiv.org/content/10.1101/2024.07.30.605893v1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.07.30.605893v1</span></a> </p><p>We found that A/bovine/OH/B24OSU-432/2024 preferentially binds to <a href="https://mstdn.science/tags/avian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>avian</span></a> type <a href="https://mstdn.science/tags/receptors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>receptors</span></a> (alpha2,3-sialosides). Sequence alignments showed that A/bovine has maintained aa in its HA associated with alpha2,3-sialoside (avian) specificity. We conclude that while we find no evidence that A/bovine has acquired human virus RB specificity, ongoing efforts must be placed on monitoring for this trait.</p>
Giuseppe Michieli<p>''For <a href="https://mstdn.science/tags/receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>receptor</span></a> <a href="https://mstdn.science/tags/binding" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>binding</span></a> <a href="https://mstdn.science/tags/analysis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>analysis</span></a> of A/Texas/37/2024, <a href="https://mstdn.science/tags/hemagglutinin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>hemagglutinin</span></a> (HA) surface protein of virus was expressed in lab &amp; tested for its ability to bind to both human- and avian-type receptors. Preliminary results show that A/Texas/37/2024 HA only binds to avian-type receptors, &amp; not to human-type receptors. This means the virus's HA has not adapted to be able to easily infect people.''</p>
Gaspar Jekely<p>By phylogenetic reconstruction, Daniel Thiel and Luis Yanez could show that <a href="https://qoto.org/tags/cnidarian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cnidarian</span></a> <a href="https://qoto.org/tags/neuropeptide" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuropeptide</span></a> receptors diversified independent from <a href="https://qoto.org/tags/GPCRs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GPCRs</span></a> in bilateria. This parallel <a href="https://qoto.org/tags/evolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>evolution</span></a> and expansion confirms that cnidarians do not represent the ancestral state in neuronal signalling (as implied by terms like 'pre-bilaterian') any more than bilaterians. <br> <a href="https://qoto.org/tags/receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>receptor</span></a> <a href="https://qoto.org/tags/evolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>evolution</span></a> <a href="https://qoto.org/tags/neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuroscience</span></a> <a href="https://qoto.org/tags/phylogeny" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>phylogeny</span></a></p>
Savani Anbalagan<p>We used <a href="https://universeodon.com/tags/STRINGdb" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>STRINGdb</span></a> to build a zebrafish-specific ligand-receptor interactome database. We also added human interactions from IID database from Jurisica group <a href="https://universeodon.com/tags/ligand" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ligand</span></a> <a href="https://universeodon.com/tags/receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>receptor</span></a> 12/n</p>
Martin Vögele<p>New <a href="https://fediscience.org/tags/preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>preprint</span></a> about PENSA, our flexible <a href="https://fediscience.org/tags/OpenSource" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>OpenSource</span></a> software package for comprehensive and thorough investigation of biomolecular conformational ensembles:</p><p><a href="https://arxiv.org/abs/2212.02714" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="">arxiv.org/abs/2212.02714</span><span class="invisible"></span></a></p><p>In three real-world examples, we show how it can be used to understand an <a href="https://fediscience.org/tags/enzyme" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>enzyme</span></a> mechanism, <a href="https://fediscience.org/tags/DNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DNA</span></a> <a href="https://fediscience.org/tags/forcefield" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>forcefield</span></a> parameters, and <a href="https://fediscience.org/tags/signaling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>signaling</span></a> in an <a href="https://fediscience.org/tags/opioid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>opioid</span></a> <a href="https://fediscience.org/tags/receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>receptor</span></a>.</p><p>Please share widely with the <a href="https://fediscience.org/tags/MolecularDynamics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MolecularDynamics</span></a> <a href="https://fediscience.org/tags/simulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>simulation</span></a> <a href="https://fediscience.org/tags/CompChem" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CompChem</span></a> <a href="https://fediscience.org/tags/MolBio" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MolBio</span></a> <a href="https://fediscience.org/tags/StructuralBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>StructuralBiology</span></a> <a href="https://fediscience.org/tags/GPCR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GPCR</span></a> communities!<br>Feedback and ideas are always welcome.</p>
Joseph P.<p>The ATP is then converted to adenosine by an enzyme called ectonucleotidase. The adenosine can then bind to either an inhibitory <a href="https://mstdn.science/tags/receptor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>receptor</span></a> (A2A or A1) or an excitatory receptor (A2A) on the <a href="https://mstdn.science/tags/postsynaptic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>postsynaptic</span></a> neuron. The adenosine is then taken up by a transporter called equilibrative nucleoside transporter (ENT) and is converted to <a href="https://mstdn.science/tags/ADP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ADP</span></a> and ATP. Finally, the A2A adenosine receptors on the <a href="https://mstdn.science/tags/blood" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>blood</span></a> vessels cause a vasodilatory effect.</p>