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#AntibioticResistance

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War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria

Now deep into its third year, Russia’s full-scale invasion of Ukraine has become a breeding ground for bacteria that can withstand the world’s most potent antibiotics. “It’s eye-opening just how incredibly resistant some of the bacteria coming out of Ukraine are. I haven’t seen anything like it,” says Jason Bennett, director of the Multidrug-Resistant Organism Repository and Surveillance Network at the Walter Reed Army Institute of Research (WRAIR).

Ringing alarm bells the loudest is Klebsiella pneumoniae, a pathogen that globally causes one in five deaths attributable to antimicrobial resistance (AMR). Disease detectives have cultured hypervirulent Klebsiella from Ukrainian casualties, including strains described in a paper in the December issue of the Journal of Infection that are pandrug resistant—in other words, no single antibiotic can vanquish them.
science.org/content/article/wa
#AntibioticResistance #medicine #XDR #bacteria

The Lancet's report on trends in deaths due to antimicrobial resistance (AMR) and ways to mitigate these deaths. thelancet.com/journals/lancet/ "Our forecasts show...an estimated 1·91 million (1·56–2·26) deaths attributable to AMR and 8·22 million (6·85–9·65) deaths associated with AMR...globally in 2050." [I]nterventions [should]combine infection prevention, vaccination, minimisation of inappropriate antibiotic use... and research into new antibiotics..." #health #publichealth #antibioticresistance

Suite du fil

Antibiotic resistance is a growing problem: More than 70 percent of hospital-acquired bacterial infections in the United States are resistant to at least one type of antibiotic. @KnowableMag reports on new twist on an old technique for addressing this that’s getting a second look: phage steering, where viruses trap bacteria in an evolutionary dilemma. Here’s more.

knowablemagazine.org/content/a

Knowable Magazine | Annual ReviewsWhat if a virus could reverse antibiotic resistance?In promising experiments, phage therapy forces bacteria into a no-win dilemma that lowers their defenses against drugs they’d evolved to withstand

#Seagrasses filter human #pathogens in marine waters phys.org/news/2024-08-seagrass

#Seagrass ecosystems as green urban infrastructure to mediate human pathogens in #seafood: Phoebe Dawkins et al. nature.com/articles/s41893-024

Coastal urban seagrass ecosystems can significantly reduce human bacterial pathogens, including those with widespread #AntibioticResistance, in marine #bivalves—a vital food source for people around the world.

Researchers at Univ Suffolk say "a reservoir of disease" is being created after discovering #bacteria naturally occur in #rivers are becoming resistant to #antibiotics due to the impact of #sewage. The university's team has isolated and analysed 500 strains of bacteria and found significant levels of #antibioticresistance.
"We're needlessly adding #pathogenic and virulence genes to bacteria found in the environment, and that could be creating a reservoir of #disease."
bbc.com/news/articles/cw4yx3wv

Soil #protists – key microbiome #predators selecting for the #bacterial antibiotic resistance
communities.springernature.com

Protistan predation selects for #AntibioticResistance in #soil bacterial communities nature.com/articles/s41396-023

"high #protist concentrations significantly enriched the abundance of genes encoding primary mechanisms of antibiotic resistance... suggesting the antibiotic production of #bacteria to fight against the predation of bacterivorous protists."