Suite du fil
And the Open access article in JAMA Network Open.
#pregnancy #placenta #science #MedMastodon
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2826174
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Options de recherche
#placenta
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“The study found that if the level of PlGF is below 100 picograms per milliliter between 24 and 28 weeks' gestation, the risk of birth before 34 weeks' gestation is almost 50-fold higher.”
#Placenta #Science #Pregnancy
https://temertymedicine.utoronto.ca/news/new-blood-test-identify-individuals-risk-preterm-birth
temertymedicine.utoronto.caA new blood test to identify individuals at risk of preterm birthA University of Toronto team led by resident Rachel Gladstone and Professor John Kingdom may have found a universal screening strategy to determine the likelihood of delivering a baby preterm. Their study concludes that a low circulating blood level of placental growth factor — a protein that signals placental development — is associated with an early preterm birth, and could signal a need for enhanced monitoring and delivery planning.
The #placenta has been proposed to harbor hemogenic endothelium that generates #HematopoieticStemCells (HSCs). This study tests this using lineage tracing analyses, but find no evidence that the placental vasculature is a site of de novo HSC formation #plosbiology https://plos.io/4hl3qZF
Two new #preLights to kick off #2025 
The trophoblast: where instability is intrinsic.
This #preprint is the first demonstration that aneuploidy is a typical feature of trophoblast stem cells & may confer cells with a developmental advantage during placental development.
Written by Carly Guiltinan 
https://prelights.biologists.com/highlights/trophoblast-aneuploidy/
preLightsChromosomal instability in human trophoblast stem cells and placentas - preLightsThe trophoblast: where instability is intrinsic
One day this August I picked up my phone and called Jens-Roger. “You know I told you the other week that I and my family were moving out?” “Yes, I remember.” “Well, I was thinking that before we leave for good, we should bury our daughter’s placenta. And we all really enjoy your place. Could we find a spot somewhere there?”
https://wildhunt.org/2024/11/putting-down-roots-digging-a-grave-saying-goodbye.html
The Wild Hunt · Putting Down Roots, Digging a Grave, Saying Goodbye
The First Two Cells in a Human Embryo Contribute Disproportionately to Fetal Development
https://www.the-scientist.com/the-first-two-cells-in-a-human-embryo-contribute-disproportionately-to-fetal-development-71841 #biology #embryology #fetal #development #totipotent #placenta #trophectoderm #InnerCe
The Scientist Magazine®The First Two Cells in a Human Embryo Contribute Disproportionately to Fetal DevelopmentA research team showed that, contrary to current models, one early embryonic cell dominates lineages that will become the fetus.
Microplastics found in every human placenta tested in study | Plastics | The Guardian
https://www.theguardian.com/environment/2024/feb/27/microplastics-found-every-human-placenta-tested-study-health-impact
#Microplastics
#Placenta
#Foetus
#UnbornBaby
#HumanBlood
#BreastMilk
#Faeces
#Poo
#IBD
#InflammatoryBowelDisease
#ToxicologicalSciences
#PVC
#Nylon
#Polyethylene
#CapitalMedicalUni
#China
#NewMexicoUni
The Guardian · Microplastics found in every human placenta tested in study
Microplastics have been found in every human placenta tested in a study, leaving the researchers worried about the potential health impacts on developing foetuses.
Prof Matthew Campen, at the University of New Mexico, US, who led the research, said: “If we are seeing effects on placentas, then all mammalian life on this planet could be impacted. That’s not good.”
The Guardian · Microplastics found in every human placenta tested in study
#Microplastics Found in Every Human #Placenta Tested, Study Finds
https://www.sciencealert.com/microplastics-found-in-every-human-placenta-tested-study-finds
ScienceAlert · Microplastics Found in Every Human Placenta Tested, Study FindsIt's been over three years since scientists first found microplastics swimming in four different human placentas, and as it turns out, that was just the tip of the iceberg.
Placental stress and Preeclampsia
“By comparing "normal" placentas with placentas from pregnancies where patients suffered from preeclampsia, investigators demonstrated that preeclampsia was associated with higher levels of cellular stresses in the syncytiotrophoblast layer on the placenta. …researchers found a hyperactive level of activity of the Gαq protein …present in excessive amounts during preeclampsia.”
#Preeclampsia #Pregnancy #Placenta #Science #Medicine
https://medicalxpress.com/news/2023-12-cellular-stress-placenta-preeclampsia.html
Medical Xpress · New research suggests cellular stress in the placenta may be possible cause of preeclampsia
And the journal article itself (open access).
#Placenta #microbiome #Development #Science
A répondu dans un fil de discussion
“Indeed, doctors discovered that some #stillbirths resulted from #COVID19 directly infiltrating the #placenta, a condition they named #SARSCoV2 #placentitis. Cases were found even in people whose COVID-19 symptoms were mild or nonexistent.”
Suite du fil
And the open access Nature Cell Biology paper
#placenta #COVID19 #pregnancy
NatureA placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts - Nature Cell BiologyChen, Neil, Tan, Rudraraju et al. use an induced trophoblast stem-cell-based model of SARS-CoV-2 infection and identify syncytiotrophoblasts as the cells targeted by the virus in the early placenta.
How the virus that causes COVID-19 can infect and damage the placenta.
Using a cell model SARS-CoV-2 infection caused significant reduction in the survival and differentiation of syncytiotrophoblast cells, which led to lower production of the human chorionic gonadotropin hormone (hCG) - needed for early pregnancy maintenance.
#pregnancy #placenta #medicine #science #ReproSci #COVID19
https://medicalxpress.com/news/2023-07-covid-placenta-lab-grown-placental-tissue.html
Medical XpressHow COVID-19 crosses the placenta: Study uses lab-grown placental tissue to model infection
Check out the fantastic upgrade our 'Living with #Covid' friends can now install, #SADS-CoV on top of #SARS-CoV-2. Sweet Lord do we need to add #'s to make any of this searchable? That's instagram-level of dysfunction ;)
Interesting discussion of the role of #complement in pathogenesis, incl. prominent role for #placenta-associated 8 protein (PLAC8) as an essential host factor #SARSCoV2 #SADSCoV https://www.pnas.org/doi/full/10.1073/pnas.2118126119 https://twitter.com/_ppmv/status/1677749026135973889 @noyes
COVID-19 during pregnancy damages the placenta's immune response to further infections https://www.news-medical.net/news/20220919/COVID-19-during-pregnancy-damages-the-placentas-immune-response-to-further-infections.aspx https://www.news-medical.net/news/20220919/COVID-19-during-pregnancy-damages-the-placentas-immune-response-to-further-infections.aspx?s=01 “But what we're seeing now is that the #placenta is vulnerable to #COVID19, and the infection changes the way the placenta works, and that in turn is likely to impact the development of the #fetus,"
"Our study suggests that babies born to mothers infected with COVID-19 at any point during their #pregnancy will need to be monitored as they grow up," she said.
News-Medical.netCOVID-19 during pregnancy damages the placenta's immune response to further infectionsIf a woman contracts COVID-19 during her pregnancy, the infection, even if it's mild, damages the placenta's immune response to further infections, a UW Medicine-led study has found.