I gather this is about reconstructing #ribosome #assembly in the #nucleolus - the PR is a bit wild but may be worth looking at the paper in Nature.
https://www.eurekalert.org/news-releases/1089618 #science #nanoworld #CellBiology #structuralBiology
I gather this is about reconstructing #ribosome #assembly in the #nucleolus - the PR is a bit wild but may be worth looking at the paper in Nature.
https://www.eurekalert.org/news-releases/1089618 #science #nanoworld #CellBiology #structuralBiology
An interesting use case of LLMs is as a conversational interface to some body of text, as a complement to other forms of navigation: from a table of content or index, via full-text search, or reading specific sections or even the whole text cover-to-cover.
Of course the LLM can still make up nonsense, but this is a similar limitation to a full-text search leading to a section irrelevant to your current question if the search terms match too broadly. With any navigation method, eventually you need to read the material once you find the section you need.
The Phenix documentation, papers, newsletters and tutorial videos have been fed to an LLM, so now we can navigate it as a conversation: https://phenix-online.org/version_docs/2.0-5725/reference/chatbot.html
A quick test trying to answer a question I knew the answer to suggests that it is working pretty well for sufficiently specific questions. This will likely be useful.
SBGrid's eLife paper received a citation in May from Joost Snijder from @utrechtuniversity in @eLife Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry.
30-May-2025
Uncovering a unique light-harvesting structure in marine #algae
Photosystem II–FCPII complex found in a marine alga could shape the future of artificial #photosynthesis
high-resolution analysis of a photosynthetic complex found in , Chrysotila roscoffensis. This marine alga belongs to the #coccolithophore species known for producing calcium carbonate plates and fixing carbon at the ocean surface.
https://www.eurekalert.org/news-releases/1085791 #science #ecology #MarineBiology #structuralBiology
How we peer review structural data | Nature Structural & Molecular Biology
Of interest to @strucbio #StructuralBiology
New Presidential executive order on proteins:
All amino acids now to be right w̶i̶n̶g̶ handed.
Leftist amino acids to be outlawed.
(Also, Z-DNA is deemed to be Communist, and is prohibited.)
Trans- and cis- peptide bonds to be banned.
Non-binary amino acid Glycine to be banned.
Proline is not a real amino acid and will be banned immediately.
Phenylalanine looks and sounds a bit like Fentanyl, banned immediately.
26-Mar-2025
Remember #ebola?
Zooming in on the #structure of the still lethal #virus
https://www.eurekalert.org/news-releases/1078261 #science #structuralBiology #protein #capsid
Our project for the SHADOC doctoral program has been selected. If you are interested to do an international #PhD in structural virology @afmblab.bsky.social , the #HellenicPasteurInstitute and #SynchrotronSoleil please visit our proposal : https://schadoc.univ-amu.fr/en/call-candidates/health-well-being/garcom
For application procedure please read carefully : https://schadoc.univ-amu.fr/en/call-candidates
Call for candidates are open between March 10th and april 21st.
@strucbio #StructuralBiology #virology #CryoEM #SXT
The authors of this paper reversed the amino acid sequence of a nanobody and apparently expected it to function like the forward sequence.
Yeah, no, that's not how proteins work.
#Science @Strucbio #StructuralBiology
https://pubpeer.com/publications/BB01ACDF81B4854C50ADF3C6B4DBBC
New #PhDstudentship available in the #Salgadolab to study #AMR bacteria, #Cdiff #BugSlayer and develop your research skills in microbiology, #structuralbiology and computational chemistry
https://shorturl.at/trW35
pls share and get in touch if you want to know more!
There is an Associate Professor Position in #Bioinformatics with a Focus on #AI Applications in Integrated #StructuralBiology available in our Institute in Marseilles (France) @afmblab.bsky.social
@afmblab.bsky.social
@strucbio @bioinformatics
The successful candidate will create his/her own team for developing and implementing innovative AI-based approaches to address key challenges in structural biology, including but not limited to:
1. Designing synthetic proteins with novel or enhanced enzymatic properties.
2. Developing synthetic protein or biomolecule binders for therapeutic or biotechnological applications.
3. Performing molecular docking of small molecules on therapeutic targets.
4. Modelling macromolecular complexes in silico.
* Contact : For more information, please contact Juan Reguera, Unit Director, including a brief CV.
Formal applications should include:
• A detailed CV with a summary of past and present research and teaching activities.
• A short description of research project and implementation plan.
• A motivation letter.
The name of my specialism is Macromolecular Crystallography.
I refine models against crystallographic data that I have collected.
Therefore I am in Macro Data Refinement I shall take no further questions.
Ok, Rab-biologists, GTP-G-S is unavailable for a couple of months. Does GMPPCP bind rabs well?
Got any references?
After years of procrastinating I finally got around to publishing my Python module for reading mmCIF files.
Check it out: https://pypi.org/project/mmcifbuddy/ and feel free to let me know how it goes!
#crystallography #structuralbiology #mmcif
cc: @strucbio @xtaldave
my features published in #CurrentBiology this year, issue 2: Reconstructing ancient #OlfactorySensors may help solve the #structures of the modern ones
https://proseandpassion.blogspot.com/2025/01/on-origins-of-smell.html #science #smell #structuralBiology #proteins #nanoworld #alphaFold
15-Jan-2025
Protein shapes can help untangle life’s ancient history
A new way of merging genomic and structural data can help dive deep into evolutionary relationships
https://www.eurekalert.org/news-releases/1070108 #science #proteins #nanoworld #evolution #structuralBiology
This is pretty amazing. TMEM206 structure determined using a single HEK cell colony!
"MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony”
Postdoctoral Scholar-Structural Biology in Protein Dynamics
Icahn School of Medicine at Mount Sinai
Join our lab as a #StructuralBiology #Postdoc to study proteins in #Alzheimers & #Cancer using #CryoEM & #XrayCrystallography at Mount Sinai!
See the full job description on jobRxiv: https://jobrxiv.org/job/icahn-school-of-medicine-at-mount-sinai...
https://jobrxiv.org/job/icahn-school-of-medicine-at-mount-sinai-27778-postdoctoral-scholar-structural-biology-in-protein-dynamics-2/?feed_id=89569
Postdoctoral Scholar-Structural Biology in Protein Dynamics
Icahn School of Medicine at Mount Sinai
Join our lab as a #StructuralBiology #Postdoc to study proteins in #Alzheimers & #Cancer using #CryoEM & #XrayCrystallography at Mount Sinai!
See the full job description on jobRxiv: https://jobrxiv.org/job/icahn-school-of-medicine-at-mount-sinai...
https://jobrxiv.org/job/icahn-school-of-medicine-at-mount-sinai-27778-postdoctoral-scholar-structural-biology-in-protein-dynamics-2/?feed_id=89072
#DeepMind finally released the code of #AlphaFold3! But with very restrictive conditions to use the model weights... And anyway, I wonder which academic lab has the hardware to run it, beside maybe David Baker's lab maybe...
#StructuralBiology #StructuralBioinformatics
Announcement: https://doi.org/10.1038/d41586-024-03708-4
Code: https://github.com/google-deepmind/alphafold3
Hardware requirements: https://github.com/google-deepmind/alphafold3/blob/main/docs/performance.md#accelerator-hardware-requirements
Form to request authorization to use the model weights: https://forms.gle/svvpY4u2jsHEwWYS6