Cannabis compound rebalances signaling to quell seizures in mice

https://www.spectrumnews.org/news/cannabis-compound-rebalances-signaling-to-quell-seizures-in-mice/

#excitatorysignaling #inhibitorysignaling #signalingimbalance #hippocampus #mousemodels #cannabis #epilepsy #autism #News #GABA

‘Splice-switching’ strategy boosts SYNGAP1 expression

https://www.spectrumnews.org/news/splice-switching-strategy-boosts-syngap1-expression/

#mousemodels #treatments #organoids #stemcells #synapses #autism #News

FDA approval of trofinetide may spur further drug development for Rett

https://www.spectrumnews.org/news/fda-approval-of-trofinetide-may-spur-further-drug-development-for-rett/

#Rettsyndrome #mousemodels #treatments #autism #MECP2 #News

Serotonin initiates earliest social bonds

https://www.spectrumnews.org/news/serotonin-initiates-earliest-social-bonds/

#sensoryperception #neuralcircuits #animalmodels #mousemodels #serotonin #oxytocin #News #rats

Debut drug for Rett syndrome at edge of approval

https://www.spectrumnews.org/news/debut-drug-for-rett-syndrome-at-edge-of-approval/

#fragileXsyndrome #Rettsyndrome #mousemodels #treatments #autism #DSM-IV #MECP2 #News

Going on Trial: Orphan drugs; CBD; bumetanide

https://www.spectrumnews.org/news/going-on-trial-orphan-drugs-cbd-bumetanide/

#inhibitorysignaling #fragileXsyndrome #clinicaltrials #Rettsyndrome #genetherapy #mousemodels #funding #autism #22q11 #MECP2 #News #FMR1

Protein networks identified in autism-linked genetic deletion

https://www.spectrumnews.org/news/protein-networks-identified-in-autism-linked-genetic-deletion/

#mousemodels #15q11-13 #autism #axons #News

Epigenome edits unmute MECP2 in Rett-like neurons

https://www.spectrumnews.org/news/epigenome-edits-unmute-mecp2-in-rett-like-neurons/

#Rettsyndrome #genetherapy #mousemodels #autism #MECP2 #News

Adult Angelman mice get some benefit from boosting UBE3A gene expression

https://www.spectrumnews.org/news/adult-angelman-mice-get-some-benefit-from-boosting-ube3a-gene-expression/

#Angelmansyndrome #clinicaltrials #geneexpression #animalmodels #genetherapy #mousemodels #treatments #autism #sleep #UBE3A #News #EEG

CHD8 mutation in 33 mouse strains yields range of traits

https://www.spectrumnews.org/news/chd8-mutation-in-33-mouse-strains-yields-range-of-traits/

#macrocephaly #mousemodels #anxiety #autism #News #CHD8

Missing mechanism helps solve fragile X protein mystery

https://www.spectrumnews.org/news/missing-mechanism-helps-solve-fragile-x-protein-mystery/

#intellectualdisability #repetitivebehaviors #socialdifficulties #fragileXsyndrome #neuralcircuits #connectivity #hippocampus #mousemodels #treatments #synapses #autism #News #FMR1 #FMRP

Beyond the bench: Finding solitude with Jill Silverman

https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-solitude-with-jill-silverman/

#Angelmansyndrome #mousemodels #autism #UBE3A #QA

Asleep in the Mouse House with Graham Diering

https://www.spectrumnews.org/news/profiles/asleep-in-the-mouse-house-with-graham-diering/

#Phelan-McDermidsyndrome #Rettsyndrome #mousemodels #Profiles #synapses #autism #SHANK3 #sleep

Autism and the cell’s antennae

https://www.spectrumnews.org/news/autism-and-the-cells-antennae/

#intellectualdisability #neurotransmitters #tuberoussclerosis #fragileXsyndrome #geneexpression #schizophrenia #mousemodels #stemcells #epilepsy #synapses #16p11.2 #autism #cortex #DYRK1A #axons #News

Calming neurons to quell seizures: Q&A with Gabriele Lignani and Dimitri Kullmann

https://www.spectrumnews.org/opinion/q-and-a/calming-neurons-to-quell-seizures-qa-with-gabriele-lignani-and-dimitri-kullmann/

#excitatorysignaling #genetherapy #mousemodels #organoids #epilepsy #autism #QA

Beyond the bench: Finding balance with Gavin Rumbaugh

https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-balance-with-gavin-rumbaugh/

#sensoryperception #neuralcircuits #mousemodels #synapses #autism #QA

The link between maternal infection and autism, explained

https://www.spectrumnews.org/news/the-link-between-maternal-infection-and-autism-explained/

#repetitivebehaviors #maternalinfection #neuralcircuits #neuralnetworks #schizophrenia #animalmodels #epidemiology #immunesystem #environment #mousemodels #microbiome #microglia #pregnancy #COVID-19 #placenta #monkeys #autism #News #ADHD #rats

Multi-omics study captures CNTNAP2’s far-ranging effects

https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/

#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News

New #colitis study from LJI's Kronenberg Lab: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034648/full

The team investigated whether increased expression of two GPRs (GPR183 and GPR18) in the intestine is related to disease severity in colitis models.