Créer un compteSe connecter

Recherches récentes

Aucune recherche récente

Options de recherche

Disponible uniquement lorsque vous êtes connecté.
mastouille.fr est l'un des nombreux serveurs Mastodon indépendants que vous pouvez utiliser pour participer au fédiverse.
Mastouille est une instance Mastodon durable, ouverte, et hébergée en France.

Administré par :

Statistiques du serveur :

685
comptes actifs

mastouille.fr: À proposAnnuaire des profilsPolitique de confidentialité

Mastodon: À proposTélécharger l’applicationRaccourcis clavierVoir le code sourcev4.3.4

#Plasmodium

0 message0 participant0 message aujourd’hui
Public
Lukas VFN 🇪🇺

How an anti-hero of the #ImmuneSystem protects from malaria blogs.biomedcentral.com/bugbit

#Autoantibodies inhibit #Plasmodium falciparum growth and are associated with protection from clinical #malaria sciencedirect.com/science/arti

"Malarial #disease and #autoimmune disease share a strange relationship. Both are best avoided, however when one is infected with the Plasmodium parasite it may be beneficial to have a propensity for autoimmunity."

fluorescence microscopy images of red blood cells
Public *
preLights

Rhoptries are essential organelles for the success of apicomplexan parasites. However, little is known about their biogenesis…

Sara Chelaghma highlights work that uncovers an unusual single-rhoptry phenotype caused by the depletion of RON11 in Plasmodium parasites. #preprint from David Anaguano & team (#MuralidharanLab)

#preLight 👉prelights.biologists.com/highl

Representative image of RON11apt schizonts showing the structure of rhoptries within fully developed merozoites in the presence and absence of 0.5 μM aTc.
#biology#malaria#plasmodium
Public
preLights

Lessons from nature for antimalarial agent discovery. 🦟 💊

John M. Bennett and colleagues (from the Fidock Lab & Bogyo Lab) develop serine hydrolase inhibitors targeting plasmodium parasites.

Preprint highlighted by Zhang-He Goh. Includes an author response! 👀 ⬇️

#preLight 👉 prelights.biologists.com/highl

#malaria #DrugResistance, #plasmodium #microbiology #pharmacology #toxicology

Summary of this work by Bennett and co-workers.
Public
Thiago Carvalho

"Overall, these data demonstrate that IL-15C treatment, via its induction of IL-10 from NK cells, modulates the dysregulated inflammation during Plasmodium infection to promote Tfh differentiation & Ab generation, correlating with improved survival from reinfection."
#Plasmodium #Malaria #InfectionImmunity #immunology

journals.aai.org/jimmunol/arti

American Association of ImmunologistsIL-15 Complex–Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody ProductionKey Points. A novel tetramer identifies endogenous Plasmodium-specific CD4+ T cells.IL-15C promotes Plasmodium-specific Tfh differentiation and Ab production.
Public *
Bunnik lab

So proud of this article about malaria that we wrote specifically for kids.

It's the result of a great collaboration with people from three different continents, including Africa!

The fantastic illustrations in the article (figures 1-4) were made by John Heim (artbyHeim@gmail.com).

kids.frontiersin.org/articles/

Frontiers for Young MindsMalaria—Why Do Mostly Children Get Sick?Did you know that micro-organisms can live in blood? Plasmodium parasites can infect red blood cells and cause a serious disease called malaria. This disease is mostly seen in young children living in Africa. Sick children have a fever, aches, can feel very tired, and in bad cases, they can even die from malaria. There are medicines that cure malaria, but it is hard to get these to everyone who needs them. Fortunately, as children grow older, they do not feel as sick when they are infected by the malaria-causing parasite. Better yet, adults hardly ever get malaria. The reason for this difference between children and adults has to do with how well the body’s defense system can fight off the parasite. Keep reading if you want to learn more about malaria, the Plasmodium parasite and how the immune system fights against it.
#malaria#kids#Plasmodium
Public
Auscandoc

“Both the newly endorsed vaccine, R21, and the earlier #vaccine, RTS,S, aim to protect against #malaria by blocking the #Plasmodium falciparum parasite before it can cause infection. They do this by targeting the parasite during the bite from a mosquito.

they contain a single protein #, the #CircumsporozoiteProtein, which coats the surface of the parasite. The vaccines aim to drive an immune response that can subsequently recognise the circumsporozoite protein,” bird.makeup/users/crabbbrendan

bird.makeupProf Brendan Crabb ACNew from @DrMichelleBoyle & myself. Big for global health, it will help defeat malaria. A great credit to all involved @JennerInstitute & beyond. New malaria vaccine: no silver bullet but an important step towards eradication https://theconversation.com/new-malaria-vaccine-no-silver-bullet-but-an-important-step-towards-eradication-215052?utm_source=twitter&utm_medium=bylinetwitterbutton via @ConversationUK
Public
Thiago Carvalho

'The extrinsic incubation period (EIP), defined as the time it takes for malaria parasites in a mosquito to become infectious to a vertebrate host, is one of the most influential parameters for malaria transmission but remains poorly understood.'

#Preprint #Malaria #Plasmodium

biorxiv.org/content/10.1101/20

bioRxivTesting a non-destructive assay to track Plasmodium sporozoites in mosquitoes over timeBackground: The extrinsic incubation period (EIP), defined as the time it takes for malaria parasites in a mosquito to become infectious to a vertebrate host, is one of the most influential parameters for malaria transmission but remains poorly understood. The EIP is usually estimated by quantifying salivary gland sporozoites in subsets of mosquitoes, which requires terminal sampling. However, assays that allow repeated sampling of individual mosquitoes over time could provide better resolution of the EIP. Methods: We tested a non-destructive assay to quantify sporozoites of two rodent malaria species, Plasmodium chabaudi and Plasmodium berghei , expelled throughout 24hr windows, from sugar-feeding substrates using quantitative PCR. Results: The assay can quantify sporozoites from sugar-feeding substrates, but the prevalence of parasite positive substrates is low. Multiple methods to increase the detection of expelled parasites (running additional technical replicates; using groups rather than individual mosquitoes) did not increase the detection rate, suggesting that expulsion of sporozoites is variable and infrequent. Conclusions: We reveal successful detection of expelled sporozoites from sugar-feeding substrates. However, investigations of the biological causes underlying the low detection rate of sporozoites (e.g. mosquito feeding behaviour, frequency of sporozoite expulsion, or sporozoite clumping) are needed to maximise the utility of using non-destructive assays to quantify sporozoite dynamics. Increasing detection rates will facilitate the detailed investigation on infection dynamics within mosquitoes, which is necessary to explain Plasmodium 's highly variable EIP and improve understanding of malaria transmission dynamics. ### Competing Interest Statement The authors have declared no competing interest.
Public
Sigrid Neuhauser

Guten Morgen! Was war gestern schön was hat euch gefreut? Es sind die kleinen Dinge die zählen. Wenn ihr mögt, lasst eure #diekleinendinge hier.

Hier: Das Weißgelbe Netzpolster lebt auf vermoderndem Holz, auf Nadelstreu oder Blättern, wo es Bakterien jagt. Als Schleimpilz ist es kein Pilze sondern gehört zu den Amoebozoa. Schleimpilze sind also mit Pilzen in etwa so nahe verwandt wie wir mit Pflanzen. #schleimpilz #myxomycete #ceratiomyxafruticulosa #biodiversity #amoebozoa #plasmodium

Ceratiomyxa porioides, Weißgelbes Netzpolster. Ein Schleimpilz, der gerade dabei ist seinen Wabenartigen Fruchtkörper zu bilden.
Public
Thiago Carvalho

"There are around 200 species of malaria parasite that can infect mammals, birds and reptiles. P. vivax is the most widely distributed form of malaria parasite in humans, and it is dominant in the Western Pacific and in highly populated areas of Latin America and Asia."

#Plasmodium #Malaria #Infection #InfectiousDisease

nature.com/articles/d41586-023

www.nature.comIn search of a vaccine for Plasmodium vivax malariaVaccinologist Arturo Reyes-Sandoval explains how researchers are edging closer to a much-needed vaccine.
Public
Thiago Carvalho

Malaria on a chip.

'A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells which allow for infection with the parasite. '

#Malaria #Plasmodium

nature.com/articles/s41598-023

NatureDevelopment of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation - Scientific ReportsA functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells which allow for infection with the parasite. Two strains of P. falciparum were used: the 3D7 strain, which is sensitive to chloroquine; and the W2 strain, which is resistant to chloroquine. The maintenance of functional cells was successfully demonstrated both in healthy and diseased conditions for 7 days in the recirculating microfluidic model. To demonstrate an effective platform for therapeutic development, systems infected with the 3D7 strain were treated with chloroquine which significantly decreased parasitemia, with recrudescence observed after 5 days. Conversely, when the W2 systems were dosed with chloroquine, parasitemia levels were moderately decreased when compared to the 3D7 model. The system also allows for the concurrent evaluation of off-target toxicity for the anti-malarial treatment in a dose dependent manner which indicates this model could be utilized for therapeutic index determination. The work described here establishes a new approach to the evaluation of anti-malarial therapeutics in a realistic human model with recirculating blood cells for 7 days.
ExplorerFlux en direct
À propos