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#Dynamics

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bioRxiv · Multiscale wrinkling dynamics in epithelial shellsThin shells buckle and wrinkle when compressed. While this behavior is generally detrimental in engineering, it has been widely implicated in epithelial morphogenesis and patterning during development. Yet the rules governing buckling of active viscoelastic shells like epithelia remain unclear. Here we delineate those rules by combining an experimental system that allows us to sculpt epithelial shells and subject them to controlled deflation with a 3D computational model linking cytoskeletal dynamics to tissue mechanics. Experiments and simulations across several orders of magnitude in time and space reveal that buckling emerges for fast deflation relative to the cortex's relaxation time, and is suppressed by high contractility. We show, further, that the tissue develops wrinkle patterns with different degrees of symmetry breaking that depend on its size and viscous confinement. Strikingly, we find that epithelial buckling is a multiscale phenomenon involving long-lived supracellular folds but also short-lived subcellular wrinkles in the actin cortex. Finally, by forming epithelial shells with anisotropic curvature we rationally direct buckling into predictable wrinkle patterns. Our study shows that epithelial tissues can be understood as hierarchical materials with mechanical instabilities that can be harnessed to engineer epithelial morphogenesis. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, CoG-681434, 101097753, Adv-883739

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

#Zoomposium with Prof. Dr. #Georg #Northoff and #Philipp #Klar: "#World + #Brain = #Consciousness? - Part 1"

It will be about the ongoing #adaptation of intrinsic #brainactivity to #environmentalstimuli. In other words, the #brain's #own #activity, the so-called “#spontaneousactivity” with its “#scale-free #dynamics” (“#nestedness”, which is measured in the “#resting-state”) must adapt to #audiovisual #inputs from the #environment.

youtu.be/J12KMGj0His

or at: philosophies.de/index.php/2025

A new COPASI version 4.45 was released.

New features:
- tool to parse arbitrary ODEs into reaction-based model.
- menu entry allowing definition and running of external tools (scripts ,etc)

Many bug fixes, including:
- better scaling for MCA in the presence of small compartment volumes
- fixed intervals for time courses running backwards (negative time)
- improvement in steady state criteria in models with conserved moieties
- Improved parsing SED-ML & SBML

copasi.org/Download/
#SystemsBiology #Chemistry #Simulation #Dynamics

copasi.orgCOPASI: DownloadCOPASI is a software application for simulation and analysis of biochemical networks and their dynamics.

It is still possible to #register for the 32nd International #dynamics & #evolution of human #viruses #conference that will be held from May 6-9, 2025 in the beautiful #abbaye of #Royaumont (north of Paris, France).

dynamicsevolution.org/event/5/

There is even room left for #childcare (from 8:30 to 17:00)!

The full program is available online with a great line up of speakers (@TanjaStadler, @chaoranchen, @firefoxx66, @famulare, ,...).

dynamicsevolution.org/event/5/